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Publications

Since the beginning of Mbale Clinical Research Institute, the institute has produced several publications which include:

Publications:

  1. Staged implementation of a two-tiered hospital-based neonatal care package in a resource-limited setting in Eastern Uganda.

    Burgoine K, Ikiror J, Akol S, Kakai M, Talyewoya S, Sande A, Otim T, Okello F, Hewitt-Smith A, Olupot-Olupot P. BMJ Glob Health. 2018 Feb 19;3(1):e000586. doi: 10.1136/bmjgh-2017-000586. eCollection 2018. Review.

    PMID:
    29527347
  2. Lactate clearance as a prognostic marker of mortality in severely ill febrile children in East Africa.

    Aramburo A, Todd J, George EC, Kiguli S, Olupot-Olupot P , Opoka RO, Engoru C, Akech SO, Nyeko R, Mtove G, Gibb DM, Babiker AG, Maitland K. BMC Med. 2018 Mar 9;16(1):37. doi: 10.1186/s12916-018-1014-x.

    PMID:
    29519240
  3. Where have all the children gone? High HIV prevalence in infants attending nutrition and inpatient entry points.

    Kiyaga C, Urick B, Fong Y, Okiira C, Nabukeera-Barungi N, Nansera D, Ochola E, Nteziyaremye J, Bigira V, Ssewanyana I, Olupot-Olupot P , Peter T, Ghadrshenas A, Vojnov L. J Int AIDS Soc. 2018 Feb;21(2). doi: 10.1002/jia2.25089.

    PMID:
    29479861
  4. Reagent Strips as an Aid to Diagnosis of Neonatal Meningitis in a Resource-limited Setting.

    Burgoine K, Ikiror J, Naizuli K, Achom L, Akol S, Olupot-Olupot P. J Trop Pediatr. 2018 Jan 29. doi: 10.1093/tropej/fmy003. [Epub ahead of print]

    PMID:
    29390160
  5. Children's Oxygen Administration Strategies Trial (COAST): A randomised controlled trial of high flow versus oxygen versus control in African children with severe pneumonia.

    Maitland K, Kiguli S, Opoka RO, Olupot-Olupot P, Engoru C, Njuguna P, Bandika V, Mpoya A, Bush A, Williams TN, Grieve R, Sadique Z, Harrison D, Rowan K. Wellcome Open Res. 2017 Oct 11;2:100. doi: 10.12688/wellcomeopenres.12747.1. eCollection 2017.

    PMID:
    29383331
  6. Realizing effectiveness across continents with hydroxyurea: Enrollment and baseline characteristics of the multicenter REACH study in Sub-Saharan Africa.

    McGann PT, Williams TN, Olupot-Olupot P, Tomlinson GA, Lane A, Luís Reis da Fonseca J, Kitenge R, Mochamah G, Wabwire H, Stuber S, Howard TA, McElhinney K, Aygun B, Latham T, Santos B, Tshilolo L, Ware RE; REACH Investigators. Am J Hematol. 2018 Aug;93(4):537-545. doi: 10.1002/ajh.25034. Epub 2018 Jan 27.

    PMID:
    29318647
  7. Assessment of Myocardial Function and Injury by Echocardiography and Cardiac Biomarkers in African Children With Severe Plasmodium falciparum Malaria.

    Kotlyar S, Olupot-Olupot P, Nteziyaremye J, Akech SO, Uyoga S, Muhindo R, Moore CL, Maitland K. Pediatr Crit Care Med. 2017 Dec 4. doi: 10.1097/PCC.0000000000001411. [Epub ahead of print]

    PMID:
    29206727
  8. Rapid Serological Tests Ineffectively Screen for Hiv Exposure in Hiv-Positive Infants.

    Urick B, Fong Y, Okiira C, Nabukeera-Barungi N, Nansera D, Ochola E, Nteziyaremye J, Bigira V, Ssewanyana I, Olupot-Olupot P, Peter T, Ghadrshenas A, Vojnov L, Kiyaga C. J Acquir Immune Defic Syndr. 2017 Nov 28. doi: 10.1097/QAI.0000000000001609. [Epub ahead of print]

    PMID:
    29206722
  9. The frequency and severity of epistaxis in children with sickle cell anaemia in eastern Uganda: a case-control study.

    Nardo-Marino A, Williams TN, Olupot-Olupot P.

    BMC Hematol. 2017 Sep 7;17:14. doi: 10.1186/s12878-017-0085-9. eCollection 2017.

    PMID:
    28912951
  10. Gastroenteritis Aggressive Versus Slow Treatment For Rehydration (GASTRO). A pilot rehydration study for severe dehydration: WHO plan C versus slower rehydration.

    Houston KA, Gibb JG, Mpoya A, Obonyo N, Olupot-Olupot P, Nakuya M, Evans JA, George EC, Gibb DM, Maitland K.

    Wellcome Open Res. 2017 Aug 10;2:62. doi: 10.12688/wellcomeopenres.12261.1. eCollection 2017.

    PMID:
    28905004
  11. Prevalence of Anaemia and Associated Risk Factors among Children in North-western Uganda: A Cross Sectional Study.

    Legason ID, Atiku A, Ssenyonga R, Olupot-Olupot P, Barugahare JB.

    BMC Hematol. 2017 Jul 3;17:10. doi: 10.1186/s12878-017-0081-0. eCollection 2017.

    PMID:
    28680644
  12. Myocardial and haemodynamic responses to two fluid regimens in African children with severe malnutrition and hypovolaemic shock (AFRIM study).

    Obonyo N, Brent B, Olupot-Olupot P, Boele van Hensbroek M, Kuipers I, Wong S, Shiino K, Chan J, Fraser J, van Woensel JBM, Maitland K.

    Crit Care. 2017 May 3;21(1):103. doi: 10.1186/s13054-017-1679-0.

    PMID:
    28468633
  13. High Frequency of Blackwater Fever Among Children Presenting to Hospital With Severe Febrile Illnesses in Eastern Uganda.

    Olupot-Olupot P, Engoru C, Uyoga S, Muhindo R, Macharia A, Kiguli S, Opoka RO, Akech S, Ndila C, Nyeko R, Mtove G, Nteziyaremye J, Chebet M, George EC, Babiker AG, Gibb DM, Williams TN, Maitland K.

    Clin Infect Dis. 2017 Apr 1;64(7):939-946. doi: 10.1093/cid/cix003.

    PMID:
    28362936
  14. Validation of triple pass 24-hour dietary recall in Ugandan children by simultaneous weighed food assessment.

    Nightingale H, Walsh KJ, Olupot-Olupot P, Engoru C, Ssenyondo T, Nteziyaremye J, Amorut D, Nakuya M, Arimi M, Frost G, Maitland K.

    BMC Nutr. 2016 Aug 24;2. pii: 56. doi: 10.1186/s40795-016-0092-4.

    PMID:
    27795836
  15. Inhibition of an Erythrocyte Tyrosine Kinase with Imatinib Prevents Plasmodium falciparum Egress and Terminates Parasitemia.

    Kesely KR, Pantaleo A, Turrini FM, Olupot-Olupot P, Low PS.

    PLoS One. 2016 Oct 21;11(10):e0164895. doi: 10.1371/journal.pone.0164895. eCollection 2016.

    PMID:
    27768734
  16. Increased adhesion of Plasmodium falciparum infected erythrocytes to ICAM-1 in children with acute intestinal injury.

    Church JA, Nyamako L, Olupot-Olupot P, Maitland K, Urban BC.

    Malar J. 2016 Feb 1;15:54. doi: 10.1186/s12936-016-1110-3.

    PMID:
    26830671
  17. Transfusion and Treatment of severe anaemia in African children (TRACT): a study protocol for a randomised controlled trial.

    Mpoya A, Kiguli S, Olupot-Olupot P, Opoka RO, Engoru C, Mallewa M, Chimalizeni Y, Kennedy N, Kyeyune D, Wabwire B, M'baya B, Bates I, Urban B, von Hensbroek MB, Heyderman R, Thomason MJ, Uyoga S, Williams TN, Gibb DM, George EC, Walker AS, Maitland K.

    Trials. 2015 Dec 29;16:593. doi: 10.1186/s13063-015-1112-4.

    PMID:
    26715196
  18. Hydroxyurea Therapy for Children With Sickle Cell Anemia in Sub-Saharan Africa: Rationale and Design of the REACH Trial.

    McGann PT, Tshilolo L, Santos B, Tomlinson GA, Stuber S, Latham T, Aygun B, Obaro SK, Olupot-Olupot P, Williams TN, Odame I, Ware RE; REACH Investigators.

    Pediatr Blood Cancer. 2016 Jan;63(1):98-104. doi: 10.1002/pbc.25705. Epub 2015 Aug 14.

    PMID:
    26275071
  19. Predicting mortality in sick African children: the FEAST Paediatric Emergency Triage (PET) Score.

    George EC, Walker AS, Kiguli S, Olupot-Olupot P, Opoka RO, Engoru C, Akech SO, Nyeko R, Mtove G, Reyburn H, Berkley JA, Mpoya A, Levin M, Crawley J, Gibb DM, Maitland K, Babiker AG.

    BMC Med. 2015 Jul 31;13:174. doi: 10.1186/s12916-015-0407-3.

    PMID:
    26228245
  20. Anaemia and blood transfusion in African children presenting to hospital with severe febrile illness.

    Kiguli S, Maitland K, George EC, Olupot-Olupot P, Opoka RO, Engoru C, Akech SO, Nyeko R, Mtove G, Reyburn H, Levin M, Babiker AG, Gibb DM, Crawley J.

    BMC Med. 2015 Feb 2;13:21. doi: 10.1186/s12916-014-0246-7.

    PMID:
    25640706
  21. Ebola in children: epidemiology, clinical features, diagnosis and outcomes.

    Olupot-Olupot P.

    Pediatr Infect Dis J. 2015 Mar;34(3):314-6. doi: 10.1097/INF.0000000000000638. Review.

    PMID:
    25522340
  22. Phase II trial of standard versus increased transfusion volume in Ugandan children with acute severe anemia.

    Olupot-Olupot P, Engoru C, Thompson J, Nteziyaremye J, Chebet M, Ssenyondo T, Dambisya CM, Okuuny V, Wokulira R, Amorut D, Ongodia P, Mpoya A, Williams TN, Uyoga S, Macharia A, Gibb DM, Walker AS, Maitland K.

    BMC Med. 2014 Apr 25;12:67. doi: 10.1186/1741-7015-12-67.

    PMID:
    24767094
  23. Spleen volume and clinical disease manifestations of severe Plasmodium falciparum malaria in African children.

    Kotlyar S, Nteziyaremye J, Olupot-Olupot P, Akech SO, Moore CL, Maitland K.

    Trans R Soc Trop Med Hyg. 2014 May;108(5):283-9. doi: 10.1093/trstmh/tru040. Epub 2014 Mar 16.

    PMID:
    24639372
  24. Authors' reply to Southall.

    Kiguli S, Akech SO, Mtove G, Opoka RO, Engoru C, Olupot-Olupot P, Nyeko R, Evans J, Crawley J, Prevatt N, Reyburn H, Levin M, George EC, South A, Babiker AG, Gibb DM, Maitland K.

    BMJ. 2014 Feb 19;348:g1619. doi: 10.1136/bmj.g1619. No abstract available.

    PMID:
    24554466
  25. WHO guidelines on fluid resuscitation in children: missing the FEAST data.

    Kiguli S, Akech SO, Mtove G, Opoka RO, Engoru C, Olupot-Olupot P, Nyeko R, Evans J, Crawley J, Prevatt N, Reyburn H, Levin M, George EC, South A, Babiker AG, Gibb DM, Maitland K.

    BMJ. 2014 Jan 14;348:f7003. doi: 10.1136/bmj.f7003. No abstract available.

    PMID:
    24423891
  26. Management of severe malaria: results from recent trials.

    Olupot-Olupot P, Maitland K.

    Adv Exp Med Biol. 2013;764:241-50. Review.

    PMID:
    23654072
  27. Endotoxaemia is common in children with Plasmodium falciparum malaria.

    Olupot-Olupot P, Urban BC, Jemutai J, Nteziyaremye J, Fanjo HM, Karanja H, Karisa J, Ongodia P, Bwonyo P, Gitau EN, Talbert A, Akech S, Maitland K.

    BMC Infect Dis. 2013 Mar 5;13:117. doi: 10.1186/1471-2334-13-117.

    PMID:
    23497104
  28. Exploring mechanisms of excess mortality with early fluid resuscitation: insights from the FEAST trial.

    Maitland K, George EC, Evans JA, Kiguli S, Olupot-Olupot P, Akech SO, Opoka RO, Engoru C, Nyeko R, Mtove G, Reyburn H, Brent B, Nteziyaremye J, Mpoya A, Prevatt N, Dambisya CM, Semakula D, Ddungu A, Okuuny V, Wokulira R, Timbwa M, Otii B, Levin M, Crawley J, Babiker AG, Gibb DM; FEAST trial group.

    BMC Med. 2013 Mar 14;11:68. doi: 10.1186/1741-7015-11-68.

    PMID:
    23496872
  29. 'The words will pass with the blowing wind': staff and parent views of the deferred consent process, with prior assent, used in an emergency fluids trial in two African hospitals.

    Molyneux S, Njue M, Boga M, Akello L, Olupot-Olupot P, Engoru C, Kiguli S, Maitland K.

    PLoS One. 2013;8(2):e54894. doi: 10.1371/journal.pone.0054894. Epub 2013 Feb 11.

    PMID:
    23408950
  30. Mortality after fluid bolus in African children with severe infection.

    Maitland K, Kiguli S, Opoka RO, Engoru C, Olupot-Olupot P, Akech SO, Nyeko R, Mtove G, Reyburn H, Lang T, Brent B, Evans JA, Tibenderana JK, Crawley J, Russell EC, Levin M, Babiker AG, Gibb DM; FEAST Trial Group.

    N Engl J Med. 2011 Jun 30;364(26):2483-95. doi: 10.1056/NEJMoa1101549. Epub 2011 May 26.

    PMID:
    21615299
  31. Orphanhood predicts delayed access to care in Ugandan children.

    Ntanda H, Olupot-Olupot P, Mugyenyi P, Kityo C, Lowes R, Cooper C, Lima V, Mills E.

    Pediatr Infect Dis J. 2009 Feb;28(2):153-5. doi: 10.1097/INF.0b013e318184eeeb.

    PMID:
    19131904
  32. Implementing a hospital based injury surveillance system in Africa: lessons learned.

    Zavalaa DE, Bokongo S, John IA, Senoga IM, Mtonga RE, Mohammed AZ, Anjango WO, Olupot-Olupot P.

    Med Confl Surviv. 2008 Oct-Dec;24(4):260-72. doi: 10.1080/13623690802373884.

    PMID:
    19065866
  33. Clinical and immunological outcomes of a national paediatric cohort receiving combination antiretroviral therapy in Uganda.

    Kiboneka A, Wangisi J, Nabiryo C, Tembe J, Kusemererwa S, Olupot-Olupot P, Joffres M, Anema A, Cooper CL, Montaner JS, Mills EJ.

    AIDS. 2008 Nov 30;22(18):2493-9. doi: 10.1097/QAD.0b013e328318f148.

    PMID:
    19005272
  34. Chronic viral hepatitis may diminish the gains of HIV antiretroviral therapy in sub-Saharan Africa.

    Cooper CL, Mills E, Wabwire BO, Ford N, Olupot-Olupot P.

    Int J Infect Dis. 2009 May;13(3):302-6. doi: 10.1016/j.ijid.2008.06.042. Epub 2008 Nov 11.

    PMID:
    19004656
  35. Adherence to antiretroviral therapy among a conflict-affected population in Northeastern Uganda: a qualitative study.

    Olupot-Olupot P, Katawera A, Cooper C, Small W, Anema A, Mills E.

    AIDS. 2008 Sep 12;22(14):1882-4. doi: 10.1097/QAD.0b013e3283112ba6.

    PMID:
    18753867
  36. Pediatric HIV therapy in armed conflict.

    Kiboneka A, Nyatia RJ, Nabiryo C, Olupot-Olupot P, Anema A, Cooper C, Mills E.

    AIDS. 2008 May 31;22(9):1097-8. doi: 10.1097/QAD.0b013e32830163c0. No abstract available.

    PMID:
    18520359
  37. A multinational injury surveillance system pilot project in Africa.

    Zavala DE, Bokongo S, John IA, Mpanga SI, Mtonga RE, Aminu ZM, Odhiambo W, Olupot-Olupot P.

    J Public Health Policy. 2007 Dec;28(4):432-41. Erratum in: J Public Health Policy. 2008 Apr;29(1):148.

    PMID:
    17955008
  38. Was the "ABC" approach (abstinence, being faithful, using condoms) responsible for Uganda's decline in HIV?

    Murphy EM, Greene ME, Mihailovic A, Olupot-Olupot P.

    PLoS Med. 2006 Sep;3(9):e379. Review.

    PMID:
    17002505
  39. Health implications of small arms and light weapons in eastern Uganda.

    Pinto AD, Olupot-Olupot P, Neufeld VR.

    Med Confl Surviv. 2006 Jul-Sep;22(3):207-19.

    PMID:
    16961122